科研成果

生命学院代表性论文

• Structural RNA components supervise the sequential DNA cleavage in R2 retrotransposon

  Deng, Pujuan; Tan, Shun-Qing; Yang, Qi-Yu; Fu, Liangzheng; Wu, Yachao; Zhu, Han-Zhou; Sun, Lei; Bao, Zhangbin; Lin, Yi; Zhang, Qiangfeng Cliff; Wang, Haoyi; Wang, Jia; Liu, Jun-Jie Gogo

  Cell

• OBOX regulates mouse zygotic genome activation and early development

  Ji, Shuyan; Chen, Fengling; Stein, Paula; Wang, Jiacheng; Zhou, Ziming; Wang, Lijuan; Zhao, Qing; Lin, Zili; Liu, Bofeng; Xu, Kai; Lai, Fangnong; Xiong, Zhuqing; Hu, Xiaoyu; Kong, Tianxiang; Kong, Feng; Huang, Bo; Wang, Qiujun; Xu, Qianhua; Fan, Qiang; Liu, Ling; Williams, Carmen J.; Schultz, Richard M.; Xie, Wei

  Nature

• Molecular basis of methyl-salicylate-mediated plant airborne defence

  Gong, Qian; Wang, Yunjing; He, Linfang; Huang, Fan; Zhang, Danfeng; Wang, Yan; Wei, Xiang; Han, Meng; Deng, Haiteng; Luo, Lan; Cui, Feng; Hong, Yiguo; Liu, Yule

  Nature

• In situ structure of the red algal phycobilisome-PSII-PSI-LHC megacomplex

  You, Xin; Zhang, Xing; Cheng, Jing; Xiao, Yanan; Ma, Jianfei; Sun, Shan; Zhang, Xinzheng; Wang, Hong-Wei; Sui, Sen-Fang

  Nature

• Nuclear export of pre-60S particles through the nuclear pore complex

  Li, Zongqiang; Chen, Shuaijiabin; Zhao, Liang; Huang, Guoqiang; Xu, Huiqin; Yang, Xiaoyun; Wang, Peiyi; Gao, Ning; Sui, Sen-Fang

  Nature

• Amyloplast sedimentation repolarizes LAZYs to achieve gravity sensing in plants

  Chen, Jiayue; Yu, Renbo; Li, Na; Deng, Zhaoguo; Zhang, Xinxin; Zhao, Yaran; Qu, Chengfu; Yuan, Yanfang; Pan, Zhexian; Zhou, Yangyang; Li, Kunlun; Wang, Jiajun; Chen, Zhiren; Wang, Xiaoyi; Wang, Xiaolian; He, Shu-Nan; Dong, Juan; Deng, Xing Wang; Chen, Haodong

  Cell

• Circadian clocks are modulated by compartmentalized oscillating translation

  Zhuang, Yanrong; Li, Zhiyuan; Xiong, Shiyue; Sun, Chujie; Li, Boya; Wu, Shuangcheng Alivia; Lyu, Jiali; Shi, Xiang; Yang, Liang; Chen, Yutong; Bao, Zhangbin; Li, Xi; Sun, Chuhanwen; Chen, Yuling; Deng, Haiteng; Li, Tingting; Wu, Qingfeng; Qi, Ling; Huang, Yue; Yang, Xuerui; Lin, Yi

  Cell

• Multifaceted SOX2-chromatin interaction underpins pluripotency progression in early embryos.

  Lijia Li,Fangnong Lai,Xiaoyu Hu,Bofeng Liu, Xukun Lu, Zili Lin, Ling Liu, Yunlong Xiang, Tristan Frum, Michael A. Halbisen, Fengling Chen, Qiang Fan, Amy Ralston, and Wei Xie

  Science

• NR5A2 connects zygotic genome activation to the first lineage segregation in totipotent embryos

  Lai, Fangnong; Li, Lijia; Hu, Xiaoyu; Liu, Bofeng; Zhu, Ziqi; Liu, Ling; Fan, Qiang; Tian, Huabin; Xu, Kai; Lu, Xukun; Li, Qing; Feng, Kong; Wang, Lijuan; Lin, Zili; Deng, Hongyu; Li, Jinsong; Xie, Wei

  Cell Research

• The compact Casπ (Cas12l) 'bracelet' provides a unique structural platform for DNA manipulation

  Sun, Ao; Li, Cheng-Ping; Chen, Zhihang; Zhang, Shouyue; Li, Dan-Yuan; Yang, Yun; Li, Long-Qi; Zhao, Yuqian; Wang, Kaichen; Li, Zhaofu; Liu, Jinxia; Liu, Sitong; Wang, Jia; Liu, Jun-Jie Gogo

  Cell Research

• Famsin, a novel gut-secreted hormone, contributes to metabolic adaptations to fasting via binding to its receptor OLFR796

  Long, Aijun; Liu, Yang; Fang, Xinlei; Jia, Liangjie; Li, Zhiyuan; Hu, Jiang; Wu, Shuang; Chen, Chao; Huang, Ping; Wang, Yiguo

  Cell Research

• A new route for EV biogenesis.

  Yu, Li

  Cell Research

• The phosphatidylinositol (4,5)-bisphosphate-Rab35 axis regulates migrasome formation

  Ding, Tianlun; Ji, Jinyao; Zhang, Weiying; Liu, Yuheng; Liu, Boqi; Han, Yiyang; Chen, Chunlai; Yu, Li

  Cell Research

• Applications of synthetic biology in medical and pharmaceutical fields

  Yan, Xu; Liu, Xu; Zhao, Cuihuan; Chen, Guo-Qiang

  Signal Transduction And Targeted Therapy

• 3-Hydroxybutyrate ameliorates insulin resistance by inhibiting PPARγ Ser273 phosphorylation in type 2 diabetic mice

  Zhang, Yudian; Li, Zihua; Liu, Xinyi; Chen, Xinyu; Zhang, Shujie; Chen, Yuemeng; Chen, Jiangnan; Chen, Jin; Wu, Fuqing; Chen, Guo-Qiang

  Signal Transduction And Targeted Therapy

• Albumosomes formed by cytoplasmic pre-folding albumin maintain mitochondrial homeostasis and inhibit nonalcoholic fatty liver disease

  Ma, Boyuan; Ju, Anji; Zhang, Shaosen; An, Qi; Xu, Siran; Liu, Jie; Yu, Li; Fu, Yan; Luo, Yongzhang

  Signal Transduction And Targeted Therapy

• Temporospatial inhibition of Erk signaling is required for lymphatic valve formation

  Meng, Yaping; Lv, Tong; Zhang, Junfeng; Shen, Weimin; Li, Lifang; Li, Yaqi; Liu, Xin; Lei, Xing; Lin, Xuguang; Xu, Hanfang; Meng, Anming; Jia, Shunji

  Signal Transduction And Targeted Therapy

• Dioxygenase JID1 mediates the modification of OPDA to regulate jasmonate homeostasis

  Yi, Rong; Du, Ran; Wang, Jiaojiao; Yan, Jijun; Chu, Jinfang; Yan, Jianbin; Shan, Xiaoyi; Xie, Daoxin

  Cell Discovery

• Cancer-cell-derived fumarate suppresses the anti-tumor capacity of CD8+T cells in the tumor microenvironment

  Cheng, Jie; Yan, Jinxin; Liu, Ying; Shi, Jiangzhou; Wang, Haoyu; Zhou, Hanyang; Zhou, Yinglin; Zhang, Tongcun; Zhao, Lina; Meng, Xianbin; Gong, Haipeng; Zhang, Xinxiang; Zhu, Haichuan; Jiang, Peng

  Cell Metabolism

• Large-scale identification of potential phase- separation proteins from plants using a cell-free system

  Zhang, Honghong; Peng, Fangyu; He, Chun; Liu, Yan; Deng, Haiteng; Fang, Xiaofeng

  Molecular Plant

• R-loopAtlas: An integrated R-loop resource from 254 plant species sustained by a deep-learning- based tool

  Li, Kuan; Wu, Zhenzhen; Zhou, Jincong; Xu, Wei; Li, Ling; Liu, Chao; Li, Wei; Zhang, Chengjun; Sun, Qianwen

  Molecular Plant

• Jasmonate perception: Ligand-receptor interaction, regulation, and evolution

  Hu, Shuai; Yu, Kaiming; Yan, Jianbin; Shan, Xiaoyi; Xie, Daoxin

  Molecular Plant

• Phase separation of the nuclear pore complex facilitates selective nuclear transport to regulate plant defense against pathogen and pest invasion

  Wang, Jiaojiao; Pei, Gaofeng; Wang, Yupei; Wu, Dewei; Liu, Xiaokang; Li, Gaoming; He, Jianfang; Zhang, Xiaolin; Shan, Xiaoyi; Li, Pilong; Xie, Daoxin

  Molecular Plant

• Custom folding of double-stranded DNA directed by triplex formation

  Zhang, Tianqing; Qian, Xinmin; Zeng, Wenwen; Wei, Bryan

  Chem

• Prolonged 3D culture unlocks black box of primate embryogenesis

  Li, Ziyi; Zhou, Fan

  Cell Stem Cell

• Incorporating neuro-inspired adaptability for continual learning in artificial intelligence

  Liyuan Wang;Xingxing Zhang;Qian Li;Mingtian Zhang;Hang Su;Jun Zhu；Yi Zhong

  Nature Machine Intelligence

• The formation of migrasomes is initiated by the assembly of sphingomyelin synthase 2 foci at the leading edge of migrating cells

  Liang, Haisha; Ma, Xinyu; Zhang, Yuanyuan; Liu, Yuheng; Liu, Nan; Zhang, Weiying; Chen, Jianhui; Liu, Boqi; Du, Wanqing; Liu, Xiaohui; Yu, Li

  Nature Cell Biology

• Sphingomyelin synthase 2 foci determine sites of migrasome formation

  Liang, Haisha; Yu, Li

  Nature Cell Biology

• MFSD12 affects glycosphingolipid metabolism by modulating lysosome homeostasis

  Hong, Yun; Tian, Zheng; Jia, Liangjie; Wang, Yiguo

  Protein & Cell

• Recent progress and challenges in the treatment of spinal cord injury

  Tian, Ting; Zhang, Sensen; Yang, Maojun

  Protein & Cell

• How variable progenitor clones construct a largely invariant neocortex

  Shen, Zhongfu, Yang, Jiajun, Zhang, Qiangqiang, Wang, Kuiyu, Hu, Xiaolin, Ma, Jjian, and Shi, Song-Hai.

  National Science Review