孟安明

教授   中国科学院院士   世界科学院院士

1979－1983，西南农业大学 本科生
1987－1990，英国诺丁汉大学 博士研究生
1990－1996，中国农业大学博士后、副教授
1996－1998，美国佐治亚医学院访问学者
1998至今，金沙js4399首页教授

●  研究兴趣、领域：

研究领域为脊椎动物胚胎早期发育的分子机制。主要以斑马鱼和小鼠为模式动物，研究胚胎卵裂期和早期囊胚的细胞命运决定机制、胚层诱导和分化的调控机制、背-腹轴和头-尾轴的形成机制等，重点关注卵源因子在这些发育过程中的作用。

●  代表性论文（2012年以来）：

1. Shen W, Gong B, Xing C, Zhang L, Sun J, Chen Y, Yang C, Yan L, Chen L, Yao L, Li G, Deng H, Wu X, Meng A. * (2022). Comprehensive maturity of nuclear pore complexes regulates zygotic genome activation. Cell 185, 4954-4970.

2. Jin, H., Han, Y., Wang, H., Li, J.X.H., Shen, W., Zhang, L., Chen, L., Jia, S., Yuan, P., Chen, H., and Meng, A. * (2022). The second polar body contributes to the fate asymmetry in the mouse embryo. Nat Sci Rev, nwac003.

3. Chen, L., Xu, W., Liu, K., Jiang, Z., Han, Y., Jin, H., Zhang, L., Shen, W., Jia, S., Sun, Q., Meng, A.* (2021). 5' Half of specific tRNAs feeds back to promote corresponding tRNA gene transcription in vertebrate embryos. Sci Adv 7, eabh0494.

4. Zhang, L., Chen, L., Chen, J., Shen, W., and Meng, A.* (2020). Mini-III RNase-based dual-color system for in vivo mRNA tracking. Development 147, dev190728.

5. Jiang, D., Jiang, Z., Lu, D., Wang, X., Liang, H., Zhang, J., Meng, Y., Li, Y., Wu, D., Huang, Y., Chen, Y., Deng, H., Wu, Q., Xiong, J., Meng, A.* and Yu, L.* (2019). Migrasomes provide regional cues for organ morphogenesis during zebrafish gastrulation. Nat Cell Biol 21, 966-977.

6. Gong, B., Li, Z., Xiao, W., Li, G., Ding, S., Meng, A.* and Jia, S*. (2019). Sec14l3 potentiates VEGFR2 signaling to regulate zebrafish vasculogenesis. Nat Commun 10, 1606.

7. Yan, L., Chen, J., Zhu, X., Sun, J., Wu, X., Shen, W., Zhang, W., Tao, Q.*, and Meng, A.* (2018). Maternal Huluwa dictates the embryonic body axis through beta-catenin in vertebrates. Science 362, eaat1045.

8. Zhang, B., Wu, X., Zhang, W., Shen, W., Sun, Q., Liu, K., Zhang, Y., Wang, Q., Li, Y., Meng, A.* and Xie, W.* (2018). Widespread Enhancer Dememorization and Promoter Priming during Parental-to-Zygotic Transition. Mol Cell 72, 673-686 e676.

9. Sun, J., Yan, L., Shen, W., and Meng, A.* (2018). Maternal Ybx1 safeguards zebrafish oocyte maturation and maternal-to-zygotic transition by repressing global translation. Development 145, dev166587.

10. Gao, Q., Zhang, J., Wang, X., Liu, Y., He, R., Liu, X., Wang, F., Feng, J., Yang, D., Wang, Z.*, Meng, A.* and Yan, X.* (2017). The signalling receptor MCAM coordinates apical-basal polarity and planar cell polarity during morphogenesis. Nat Commun 8, 15279.

11. Liu, Z., Ning, G., Xu, R., Cao, Y., Meng, A.* and Wang, Q.* (2016). Fscn1 is required for the trafficking of TGF-beta family type I receptors during endoderm formation. Nat Commun 7, 12603.

12. Zhang, J., Jiang, Z., Liu, X. and Meng, A.* (2016). Eph/ephrin signaling maintains the boundary of dorsal forerunner cell cluster during morphogenesis of the zebrafish embryonic left-right organizer. Development 143, 2603-2615.

13. Xue, Y., Zheng, X., Huang, L., Xu, P., Ma, Y., Min, Z., Tao, Q., Tao, Y.*, and Meng, A*. (2014) Organizer-derived Bmp2 is required for the formation of a correct Bmp activity gradient during embryonic development. Nat Commun 5, 3766.

14. Xu, P., Zhu, G., Wang, Y., Sun, J., Liu, X., Chen, Y. G., and Meng, A*. (2014) Maternal Eomesodermin regulates zygotic nodal gene expression for mesendoderm induction in zebrafish embryos. J Mol Cell Biol 6, 272-285.

15. Liu, X., Xiong, C., Jia, S., Zhang, Y., Chen, Y. G., Wang, Q., and Meng, A*. (2013) Araf kinase antagonizes Nodal-Smad2 activity in mesendoderm development by directly phosphorylating the Smad2 linker region. Nat Commun 4, 1728.

 

●  荣誉、奖励及参加学术团体的情况：

获得何梁何利科技进步奖、谈家桢生命科学成就奖等奖励。现任中国动物学会理事长，中国遗传学会副理士长；先后任National Science Open、National Science Reviews、Development、Journal of Molecular Cell Biology、Open Biology、BMC Developmental Biology、Journal of Cell Science、Current Zoology、Journal of Genetics and Genomics、Cell Research、Mechanisms of Development等杂志编委会或顾问委员会成员。

●  联系方式：

电话：+86-10-62772256
E-mail:mengam@mail.tsinghua.edu.cn