陶庆华 博士

教授

1988-1992      四川大学生物工程系遗传学专业 学士

1995-2000      中科院上海细胞所发育生物学专业 博士

2000-2008     美国俄亥俄州辛辛那提市儿童医院发育生物学系 博士后，研究助理

2008-至今 金沙js4399首页 教授

●  研究兴趣、领域：

综合运用基因组学、蛋白质组学、分子生物学、遗传学等技术，研究脊椎胚胎早期发育中的细胞命运决定和分化的分子机理，助力人类先天性疾病、发育不良结局机理探索。

1、 胚胎发育的跨代调控机理：

    1）母源因子如何调控胚胎背腹体轴决定（母源决定因子“葫芦娃”课题方向Science 2018）。

    2) bHLH家族母源转录因子调控胚层决定于分化的机理研究。

    3）新亲源（母源、父源）因子的分离与鉴定。

2、 受精卵及早期胚胎发育的代谢调控与自组织机理研究。

3、 Wnt, TGF-β, FGF等生长因子诱导胚胎多潜能细胞定向分化的机理。

●  代表性论文：

1. Zhu XC, Wang P, Wei JL, Li YY, Zhai JY, Zheng TR, Tao QH* (2021) Lysosomal degradation of the maternal dorsal determinant Hwa to safeguard dorsal body axis formation. EMBO Rep. 22(12): e53185.

2. Zhang FF, Zhuc XC, Wang P, He Q, Huang HM, Zheng TR, Li YY, Jia H, Xu LP, Zhao HX, Colozza G, Tao QH*, De Robertis EM* and Ding Y* (2021) The Cytokine FAM3B/PANDER is an FGFR Ligand that Promotes Posterior Development in Xenopus. PNAS, 2021 May 18, 118 (20) e2100342118.

3. Yan L, Chen J, Zhu XC, Sun JW, Wu XT, Shen WM, Zhang WY, Tao QH*, Meng AM* (2018) Maternal Huluwa Dictates the Embryonic Body Axis through b-catenin in Vertebrates. Science 362(6417). pii: eaat1045. .

4. Lin H, Zhu XC, Chen G, Song L, Gao L, Khand AA, Chen Y, Lin GF*, Tao QH* (2017) KDM3A-mediated dimethylation of histone H3 lysine 9 facilitates the chromatin binding of Neurog2 during neurogenesis. Development 144(20): 3674-3685.

5. Zhu XC, Xing R, Tan RB, Dai RY, Tao QH (2017) The RNF146 E3 ubiquitin ligase is required for the control of Wnt signaling and body pattern formation in Xenopus. Mech. Dev. 147: 28-36. doi: 10.1016/j.mod. 2017.08.001.

6. Gao L, Zhu XC, Chen G, Ma X, Zhang Y, Khand A, Shi H, Gu F, Lin H, Chen Y, Zhang H, He L, Tao QH* (2016) A novel role for Ascl1 in the regulation of mesendoderm formation via HDAC-dependent antagonism of VegT function. Development 143(3):492-503.

7. Lin H, Min Z, Tao QH* (2016) The MLL/Setd1b methyltransferase is required for the Spemann’s organizer gene activation in Xenopus. Mech. Dev. 142:1-9.

8. Zhang Y, Ding Y, Chen YG*, Tao QH* (2014) NEDD4L regulates convergent extension movements in Xenopus embryos via Dishevelled-mediated non-canonical Wnt signaling. Dev. Biol.  392(2014): 15-25.

9. Ding Y, Zhang Y, Xu C, Tao QH* and Chen YG* (2013) HECT Domain-containing E3 ubiquitin ligase NEDD4L negatively regulates Wnt signaling by targeting Dishevelled for proteasomal degradation. J. Biol. Chem. 288, 8289-98.

10. Tao QH, Yokota C, Puck H, Kofron M, Birsoy B, Dong Y, Asashima M, Wylie C, Lin X and  Heasman J. (2005a). Maternal Wnt11 activates the canonical Wnt signaling pathway required for axis formation in Xenopus embryos. Cell 120:857-871.

●  联系方式：

电话：86-10-62788745

Email: qhtaolab@mail.tsinghua.edu.cn